Applications

Review articles
  • Y. Y. Hui and H.-C. Chang, “Recent developments and applications of nanodiamonds as versatile bioimaging agents,” J. Chin. Chem. Soc. 61, 67–76 (2014). Link
  • Y. Y. Hui, C.-L. Cheng, and H.-C. Chang, “Nanodiamonds for optical bioimaging,” J. Phys. D: Appl. Phys. 43, 374021 (2010). Link
  • C.-C. Wu, C.-C. Han, and H.-C. Chang, “Applications of surface-functionalized diamond nanoparticles for mass-spectrometry-based proteomics,” J. Chin. Chem. Soc. 57, 582−594 (2010). Link
  • V. Vaijayanthimala and H.-C. Chang, “Functionalized fluorescent nanodiamonds for biomedical applications,” Nanomed. 4, 47−55 (2009). Link

Biocompatibility
  • T.-C. Hsu, K.-K. Liu, H.-C. Chang, E. Hwang, and J.-I. Chao, “Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds,” Sci. Rep. 4, 5004 (2014). Link
  • H.-C. Li, F.-J. Hsieh, C.-P. Chen, M.-Y. Chang, P. C. H. Hsieh, C.-C. Chen, S.-U. Hung, C.-C. Wu, and H.-C. Chang, “The hemocompatibility of oxidized diamond nanocrystals for biomedical applications,” Sci. Rep. 3, 3044 (2013). Link
  • V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao, J.-I Chao, and H.-C. Chang, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794−7802 (2012). Link
  • V. Vaijayanthimala, Y.-K. Tzeng, H.-C. Chang, and C.-L. Li, “The biocompatibility of fluorescent nanodiamonds and their mechanism of cellular uptake,” Nanotechnology 20, 425103 (2009). Link
FND production
  • L.-J. Su, C.-Y. Fang, Y.-T. Chang, K.-M. Chen, Y.-C. Yu, J.-H. Hsu, and H.-C. Chang, “Creation of high density ensembles of nitrogen-vacancy centers in nitrogen-rich type Ib nanodiamonds,” Nanotechnology 24, 315702 (2013) Link
  • N. Mohan, Y.-K. Tzeng, L. Yang, Y.-Y. Chen, Y. Y. Hui, C.-Y. Fang, and H.-C. Chang, “Sub-20-nm fluorescent nanodiamonds as photostable biolabels and fluorescence resonance energy transfer donors,” Adv. Mater. 22, 842−847 (2010). Link
  • T.-L. Wee, Y.-W. Mau, C.-Y. Fang, H.-L. Hsu, C.-C. Han, and H.-C. Chang, “Preparation and characterization of green fluorescent nanodiamonds for biological applications,” Diamond Relat. Mater. 18, 567−573 (2009). Link
  • Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang, and W. Fann, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nature Nanotech. 3, 284−288 (2008). Link
  • S.-J. Yu, M.-W. Kang, H.-C. Chang, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604−17605 (2005). Link
 
Photoluminescence imaging
  • Y. Y. Hui, L.-J. Su, O. Y. Chen, Y.-T. Chen, T.-M. Liu, and H.-C. Chang, “Wide-field imaging and flow cytometric analysis of cancer cells in blood by fluorescent nanodiamond labeling and time gating,” Sci. Rep. 4, 5574 (2014). Link
  • Z. Chu, S. Zhang, B. Zhang, C. Zhang, C.-Y. Fang, I. Rehor, P. Cigler, H.-C. Chang, G. Lin, R. Liu, and Q. Li, “Unambiguous observation of shape effects on cellular fate of nanoparticles,” Sci. Rep. 4, 4495 (2014). Link
  • B.-M. Chang, H.-H. Lin, L.-J. Su, W.-D. Lin, R.-J. Lin, Y.-K. Tzeng, R. T. Lee, Y. C. Lee, A. L. Yu, and H.-C. Chang, “Highly fluorescent nanodiamonds protein-functionalized for cell labeling and targeting,” Adv. Funct. Mater. 23, 5737–5745 (2013). Link
  • T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang, and J. Yu, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nature Nanotech. 8, 682–689 (2013). Link
  • Y. Kuo, T.-Y. Hsu, Y.-C. Wu, and H.-C. Chang, “Fluorescent nanodiamond as a probe for the intercellular transport of proteins in vivo,” Biomaterials 34, 8352−8360 (2013). Link
  • C.-Y. Fang, V. Vaijayanthimala, C.-A. Cheng, S.-H. Yeh, C.-F. Chang, C.-L. Li, and H.-C. Chang, “The exocytosis of fluorescent nanodiamond and its use as a long-term cell tracker,” Small 7, 3362−3370 (2011). Link
  • N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu, and H.-C. Chang, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692−3699 (2010). Link
  • B. Zhang, Y. Li, C.-Y. Fang, C.-C. Chang, C.-S. Chen, Y.-Y. Chen, and H.-C. Chang, “Receptor-mediated cellular uptake of folate-conjugated fluorescent nanodiamonds: A combined ensemble and single-particle study,” Small 5, 2716−2721 (2009). Link
  • C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.- Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang, and W. Fann, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA 104, 727−732 (2007). Link
 
Two-photon excitation imaging
  • Y. Y. Hui, B. Zhang, Y.-C. Chang, C.-C. Chang, H.-C. Chang, J.-H. Hsu, K. Chang, and F.-H. Chang, “Two-photon fluorescence correlation spectroscopy of lipid-encapsulated fluorescent nanodiamonds in living cells,” Opt. Express 18, 5896−5905 (2010). Link
  • T.-L. Wee, Y.-K. Tzeng, C.-C. Han, H.-C. Chang, W. Fann, J.-H. Hsu, K.-M. Chen, and Y.-C. Yu, “Two-photon excited fluorescence of nitrogen-vacancy centers in proton-irradiated type Ib diamond,” J. Phys. Chem. A 111, 9379−9386 (2007). Link
 
Superresolution imaging
  • X. Yang, Y.-K. Tzeng, Z. Zhu, Z. Huang, X. Chen, Y. Liu, H.-C. Chang, L. Huang, W.-D. Li, and P. Xi, “Sub-diffraction imaging of nitrogen-vacancy centers in diamond by stimulated emission depletion and structured illumination,” RSC Adv. 4, 11305–11310 (2014). Link
  • Y. Y. Hui, Y.-C. Lu, L-J. Su, C.-Y. Fang, J.-H. Hsu, and H.-C. Chang, “Tip-enhanced sub-diffraction fluorescence imaging of nitrogen-vacancy centers in nanodiamonds,” Appl. Phys. Lett. 102, 013102 (2013). Link
  • Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262−2265 (2011). Link
  • M. Yamanaka, Y.-K. Tzeng, S. Kawano, N. I. Smith, S. Kawata, H.-C. Chang, and K. Fujita, “SAX microscopy with fluorescent nanodiamond probes for high-resolution fluorescence imaging,” Biomed. Opt. Express 2, 1946−1954 (2011). Link
 
Photoacoustic imaging
  • T. Zhang, H. Cui, C.-Y. Fang, L.-J. Su, H.-C. Chang, X. Yang, and M. L. Forrest, “Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance,” J. Biomed. Opt. 18, 026018 (2013). Link
  • B. Zhang, C.-Y. Fang, C.-C. Chang, R. Peterson, S. Maswadi, R. D. Glickman, H.-C. Chang, and J. Y. Ye, “Photoacoustic emission from fluorescent nanodiamonds enhanced with gold nanoparticles,” Biomed. Opt. Express 3, 1662−1669 (2012). Link
 
Cathodoluminescence imaging
  • Y. Nawa, W. Inami, S. Lin, Y. Kawata, S. Terakawa, C.-Y. Fang, and H.-C. Chang, “Multicolor imaging of fluorescent nanodiamonds in living HeLa cells using direct electron-beam excitation,” ChemPhysChem 15, 721–726 (2014). Link
  • L. H. G. Tizei, S. Meuret, S. Nagarajan, F. Treussart, C.-Y. Fang, H.-C. Chang, and M. Kociak, “Spatially and spectrally resolved cathodoluminescence with fast electrons: A tool for background subtraction in luminescence intensity second-order correlation measurements applied to subwavelength inhomogeneous diamond nanocrystals,” Phys. Status Solidi A 210, 2060–2065 (2013). Link
 
ND-based solid phase extraction
  • C.-C. Hsieh, J. Y. Guo, S.-U. Hung, R. Chen, Z. Nie, H.-C. Chang, and C.-C. Wu, “Quantitative analysis of oligosaccharides derived from sulfated glycosaminoglycans by nanodiamond-based affinity purification and MALDI MS,” Anal. Chem. 85, 4342−4349 (2013). Link
  • C.-K. Chang, C.-C. Wu, Y.-S. Wang, and H.-C. Chang, “Selective extraction and enrichment of multi-phosphorylated peptides using polyarginine-coated diamond nanoparticles,” Anal. Chem. 80, 3791−3797 (2008). Link
  • Y.-K. Tzeng, C.-C. Chang, C.-N. Huang, C.-C. Wu, C.-C. Han, and H.-C. Chang, “Facile MALDI-MS analysis of neutral glycans in NaOH-doped matrices: Microwave-assisted deglycosylation and one-step purification with diamond nanoparticles,” Anal. Chem. 80, 6809−6814 (2008). Link
  • T. T. B. Ngyuen, H.-C. Chang, and V. W.-K. Wu, “Adsorption and hydrolytic activity of lysozyme on diamond nanocrystallites,” Diamond Relat. Mater. 16, 872−876 (2007). Link
  • S. Sabu, F.-C. Yang, Y.-S. Wang, W.-H. Chen, H.-C. Chang, and C.-C. Han, “Peptide analysis: Solid phase extraction-elution on diamond (SPEED) combined with atmospheric pressure MALDI-FTICR mass spectrometry,” Anal. Biochem. 367, 190−200 (2007). Link
  • W.-H. Chen, S.-C. Lee, S. Sabu, H.-C. Fang, S.-C. Chung, C.-C. Han, and H.-C. Chang, “Solid phase extraction and elution on diamond (SPEED): A fast and general platform for proteome analysis with mass spectrometry,” Anal. Chem. 78, 4228−4234 (2006). Link
  • X. L. Kong, L. C. L. Huang, S.-C. V. Liau, C.-C. Han, and H.-C. Chang, “Polylysine-coated diamond nanocrystals for MALDI-TOF mass analysis of DNA oligonucleotides,” Anal. Chem. 77, 4272−4277 (2005). Link
  • X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259−265 (2005). Link
  • L. C. L. Huang and H.-C. Chang, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir 20, 5879−5884 (2004). Link
 
Others
  • H. Kaupp, C. Deutsch, H.-C. Chang, J. Reichel, T. W. Hänsch, and D. Hunger, “Scaling laws of the cavity enhancement for nitrogen-vacancy centers in diamond,” Phys. Rev. A 88, 053812 (2013). Link
  • A. Ermakova, G. Pramanik, J.-M. Cai, G. Algara-Siller, U. Kaiser, T. Weil, Y.-K. Tzeng, H.-C. Chang, L. P. McGuinness, M. B. Plenio, B. Naydenov, and F. Jelezko, “Detection of a few metallo-protein molecules using color centers in nanodiamonds,” Nano Lett. 13, 3305−3309 (2013). Link
  • N. D. Lai, O. Faklaris, D. Zheng, V. Jacques, H.-C. Chang, J.-F. Roch, and F. Treussart, “Quenching nitrogen-vacancy center photoluminescence with infrared pulsed laser,” New J. Phys. 15, 033030 (2013). Link
  • J.-H. Hsu, W.-D. Su, K.-L. Yang, Y.-K. Tzeng, and H.-C. Chang, “Non-blinking green emission from single H3 color centers in nanodiamonds,” Appl. Phys. Lett. 98, 193116 (2011). Link
  • Y.-Y. Chen, H. Shu, Y. Kuo, Y.-K. Tzeng, and H.-C. Chang, “Measuring Förster resonance energy transfer between fluorescent nanodiamonds and near-infrared dyes by acceptor photobleaching,” Diamond Relat. Mater. 20, 802−807 (2011). Link
  • Y. Y. Hui,Y.-R. Chang, N. Mohan, T.-S. Lim, Y.-Y. Chen, and H.-C. Chang, “Polarization modulation spectroscopy of single fluorescent nanodiamonds with multiple nitrogen-vacancy centers,” J. Phys. Chem. A 115, 1878−1884 (2011). Link
  • L. Rondin, G. Dantelle, A. Slablab, F. Treussart, P. Bergonzo,S. Perruchas, T. Gacoin, H.-C. Chang, V. Jacques, and J.-F. Roch, “Surface-induced charge state conversion of nitrogen-vacancy defects in nanodiamonds,” Phys. Rev. B 82, 115449 (2010). Link
  • T.-S. Lim, C.-C. Fu, K.-C. Lee, H.-Y. Lee, K. Chen, W.-F. Cheng, W. W. Pai, H.-C. Chang, and W. Fann, “Fluorescence enhancement and lifetime modification of single nanodiamonds near a nanocrystalline silver surface,” Phys. Chem. Chem. Phys. 11, 1508−1514 (2009). Link